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Vaccine Effectiveness and Duration of Protection Two clinical trials found Rotarix to have 85 to 96% protection against severe rotavirus gastroenteritis through two rotavirus seasons (December through June). One study found Rotarix to be 96% effective in reducing hospitalizations through two rotavirus seasons.
Vaccines RecommendationRV5 (RotaTeq)RV1 (Rotarix)Recommended ages for doses2, 4, and 6 months of age2 and 4 months of ageMinimum age for first dose6 weeks of age6 weeks of ageMaximum age for first dose14 weeks, 6 days of age14 weeks, 6 days of ageMinimum interval between doses4 weeks4 weeks2 more rows
Rotavirus Vaccine Schedule May be started as early as age 6 weeks. Maximum age for first dose is 14 weeks 6 days* Minimum interval between doses is 4 weeks. Maximum age for any dose is 8 months 0 days*
Conclusions: Vaccine effectiveness of RV1 and RV5 was somewhat lower against nonvaccine than vaccine strains. Ongoing surveillance is important to continue long-term monitoring for strain replacement, particularly in low-income settings where data are limited.
Among children

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RotaTeq is given in three doses at ages 2 months, 4 months, and 6 months. Rotarix is given in two doses at ages 2 months and 4 months.
CDC recommends that infants get rotavirus vaccine to protect against rotavirus disease. Two rotavirus vaccines are currently licensed for use in infants in the United States. RotaTeq (RV5) has been approved for use since 2006, and is given in three doses at 2 months, 4 months, and 6 months of age.
The first dose of either vaccine should be given before a child is 15 weeks of age. Children should receive all doses of rotavirus vaccine before they turn 8 months old. Both vaccines are given by putting drops in the childs mouth.

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