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What drugs are androgen inhibitors?

Antiandrogens. Direct androgen receptor antagonists in general use in PCOS patients include spironolactone (SPA), flutamide (FLUT), and the progestogen, cyproterone acetate (CPA). SPA is the most commonly used androgen inhibitor in the United States, while CPA and FLUT are more widely used elsewhere. Androgen Inhibitor - an overview | ScienceDirect Topics sciencedirect.com medicine-and-dentistry sciencedirect.com medicine-and-dentistry

What is inhibition of androgen production?

An androgen synthesis inhibitor is a type of drug which inhibits the enzymatic synthesis of androgens, such as testosterone and dihydrotestosterone (DHT). They include: CYP17A1 inhibitors (17-hydroxylase/17,20-lyase inhibitors): inhibit the synthesis of androgens from pregnanes. Androgen synthesis inhibitor - Wikipedia wikipedia.org wiki Androgensynthesisin wikipedia.org wiki Androgensynthesisin

What are the active androgen receptors?

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone, in the cytoplasm and then translocating into the nucleus. Androgen receptor - Wikipedia wikipedia.org wiki Androgenreceptor wikipedia.org wiki Androgenreceptor

What are androgen signaling inhibitors?

A substance that keeps androgens (male sex hormones) from binding to proteins called androgen receptors, which are found in normal prostate cells, some prostate cancer cells, and in cells of some other tissues. Preventing this binding blocks the effects of these hormones in the body. Definition of androgen receptor blocker - National Cancer Institute cancer.gov dictionaries cancer-terms def cancer.gov dictionaries cancer-terms def

What is androgenic signaling?

Androgen signaling plays a pivotal role in the development and function of a normal prostate gland. There are two native androgens in humans, testosterone (T), and 5-dihydrotestosterone (DHT). Testosterone is produced mainly in the testis, with a small amount being produced in the adrenal glands in men. Androgen Receptor Signaling in the Development of Castration frontiersin.org fonc.2019.00858 full frontiersin.org fonc.2019.00858 full

What are AR antagonists for prostate cancer?

For most prostate cancer cells to grow, androgens have to attach to a protein in the prostate cancer cell called an androgen receptor. Anti-androgens, also called androgen receptor antagonists, are drugs that connect to androgen receptors, which stops the androgens from fueling tumor growth. Hormone Therapy for Prostate Cancer | American Cancer Society cancer.org types prostate-cancer treating cancer.org types prostate-cancer treating

What does androgen receptor do?

By turning the genes on or off as necessary, the androgen receptor helps direct the development of male sexual characteristics. Androgens and androgen receptors also have other important functions in both males and females, such as regulating hair growth and sex drive. AR gene: MedlinePlus Genetics medlineplus.gov genetics gene medlineplus.gov genetics gene

What is androgen receptor degraders for prostate cancer?

PROTAC AR degraders overcome common resistance mechanisms developed during prostate cancer treatment with AR antagonists. Good progress of AR degraders in Phase I/II fully demonstrates the highly clinical value of PROTAC strategy in treatment of human diseases. Review Targeting androgen receptor degradation with PROTACs from sciencedirect.com science article pii sciencedirect.com science article pii

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