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Tularemia Investigation Guideline - Kansas Department of Health - kdheks

Tularemia Investigation Guideline - Kansas Department of Health - kdheks 2025

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The document provides comprehensive guidelines for the investigation and management of tularemia, a highly infectious disease caused by the bacterium Francisella tularensis. It includes case definitions, clinical descriptions, laboratory criteria for diagnosis, epidemiology, treatment options, and protocols for reporting to public health authorities. The guidelines emphasize the importance of identifying potential sources of infection, managing laboratory exposures, and implementing control measures to prevent disease spread. Additionally, it addresses the need for education on prevention and outlines responsibilities for health investigators.

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What is the gold standard Test for tularemia?

Tularemia diagnosis can be established serologically or by culture or PCR detection of F. tularensis from clinical samples (Trnvik and Chu, 2007; Hepburn and Simpson, 2008; Maurin, 2020; Wawszczak et al., 2022). Culture and PCR tests may allow an early and specific diagnosis of tularemia.

How do you investigate tularemia?

The diagnosis of tularemia can also be made by rapid laboratory tests, such as direct fluorescent antibody (DFA) and real-time polymerase chain reaction (PCR), or by serology demonstrating a 4-fold change in antibody titers between acute and convalescent sera.

Is tularemia reportable?

Tularemia is also reportable if it is a cause or suspected cause of an outbreak, which would be an uncommon situation given its usual modes of spread.

What is the lab test for tularemia?

Diagnostic testing options for F tularensis primarily include culture and serology. Providers suspecting tularemia should collect appropriate specimens (eg, skin lesion biopsy, lymph node aspirates) promptly and send for culture.

What is doc for tularemia?

Streptomycin is the drug of choice (DOC) for this treatment; although less experience exists with other aminoglycosides, gentamicin also appears to be effective. In addition, although tetracyclines are acceptable alternatives, increasing research supports the use of fluoroquinolones in the treatment of tularemia.

What tests are done to diagnose tularemia?

What tests will be done to diagnose tularemia? Blood tests. A sample of blood taken from your arm will be sent to a lab. Biopsy. If you have large lymph nodes or ulcers, your provider may take a sample of your tissue for biopsy. Nasal or throat swab. Pleural fluid test (thoracentesis).

What is the gold standard test for tularemia?

Serology is still considered to be a cornerstone in tularemia diagnosis due to the low sensitivity of bacterial culture and the lack of standardization in PCR methodology for the direct identification of the pathogen. We developed a novel immunochromatographic test (ICT) to efficiently detect F.

What is a tularemia antibody?

If antibodies are detected, there has been exposure to F tularensis. If antibodies are found, it means you either have a current or past infection with F tularensis. In some cases, a single high level of antibodies that are specific to F tularensis means you have an infection.

Tularemia Investigation Guideline - Kansas Department of Health - kdheks 2025

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