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The safety of vaccines is thoroughly studied before they are licensed for public use. Clinical trials are conducted to evaluate the safety and effectiveness of a vaccine before it can be brought to market. Vaccines are first tested in laboratory studies and animal studies.
Common Vaccine Safety Questions and Concerns Vaccine Adjuvants (Additives) Autism and Vaccines. Fainting (Syncope) Febrile Seizures after Childhood Vaccinations. Guillain-Barr Syndrome (GBS) Sudden Infant Death Syndrome (SIDS) Thimerosal (Preservative used in Some Flu Vaccines) Multiple Vaccines and the Immune System.
Also included within the spectrum of potential adjuvant systemic toxicity is the potential for chronic organ toxicity of the compounds themselves. For example, aluminium or oil emulsions can form long-term tissue depots, and this has been postulated to cause chronic toxic effects.
Vaccines are extensively studied before widespread use. Vaccines have used and continue to use double-blind placebo-controlled studies to prove that they are effective and safe in the people who receive them.
Once vaccines are introduced and used in countries, national health authorities continuously monitor vaccine safety to detect and immediately respond to potential concerns. In case of an adverse event, an independent group of experts assesses whether such an event is related to vaccines.

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Generally, injected vaccines have high bioavailability because they are directly injected into the bloodstream, bypassing the digestive system. Oral vaccines, on the other hand, have lower bioavailability because they must pass through the digestive system before being absorbed.
A separate needle and syringe should be used for each injection. Changing needles between drawing vaccine from a vial and injecting it into a recipient is not necessary unless the needle has been damaged or contaminated (11).
However, not all vaccines need adjuvants. For example, licensed conjugated meningococcal vaccines do not contain adjuvants because the conjugation itself with a protein carrier is able to stimulate a good immune response [12].

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