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Since then, the protein folding problem has come to be regarded as three different problems: (a) the folding code: the thermodynamic question of what balance of interatomic forces dictates the structure of the protein, for a given amino acid sequence; (b) protein structure prediction: the computational problem of how The Protein Folding Problem - PMC - NCBI National Institutes of Health (NIH) (.gov) articles PMC2443096 National Institutes of Health (NIH) (.gov) articles PMC2443096
What was the protein folding problem?
The protein folding problem consists of three closely related puzzles: (a) What is the folding code? (b) What is the folding mechanism? (c) Can we predict the native structure of a protein from its amino acid sequence? Once regarded as a grand challenge, protein folding has seen great progress in recent years. The protein folding problem - PubMed nih.gov nih.gov
What is the protein folding error?
The misfolding of proteins can trigger the further misfolding and accumulation of other proteins into aggregates or oligomers. The increased levels of aggregated proteins in the cell leads to formation of amyloid-like structures which can cause degenerative disorders and cell death.
What is the Levinthals paradox?
Abstract. Levinthals paradox is that finding the native folded state of a protein by a random search among all possible configurations can take an enormously long time. Yet proteins can fold in seconds or less. Levinthals paradox. - PMC - NCBI nih.gov articles PMC48166 nih.gov articles PMC48166
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The Protein Folding Problem
by KA Dill 2008 Cited by 1355 The protein folding problem is the question of how a proteins amino acid sequence dictates its three-dimensional atomic structure. The notion of a folding
Ab initio simulations of protein-folding pathways by
by A Liwo 2005 Cited by 338 There are two protein-folding problems in contemporary computational biology. The first problem is to predict protein structure from sequence,
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