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What is a Select Agent? Select agents are biological agents and toxins that have been determined to have the potential to pose a severe threat to public health and safety, to animal and plant health, or to animal or plant products. There are 68 select agents and toxins regulated by the Federal Select Agent program.
The Centers for Disease Control and Prevention (CDC) has been designated as the HHS agency responsible for promulgating, implementing, and providing guidance on 42 CFR Part 73. The HHS Select Agent regulations can be found in Part 73 of Title 42 of the Code of Federal Regulations (42 CFR Part 73).
Tier 1 Select agents and toxins A subset of select agents and toxins have been designated as Tier 1 because these biological agents and toxins present the greatest risk of deliberate misuse with docHub potential for mass casualties or devastating effect to the economy, critical infrastructure, or public
Infectious agents and toxins considered by the Department of Health and Human Services (HHS) or the Department of Agriculture (USDA) as having the potential to pose a severe threat to human, animal, or plant health are regulated as select agents.
A select agent is a biological agent or toxin that has the potential to pose a severe threat to public health and safety, animal or plant health, or animal or plant product.
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Excluded Attenuated Strains of HHS Select Agents, Section 73.3 (e) Botulinum neurotoxin producing species of Clostridium. Coxiella burnetii. Eastern Equine Encephalitis virus. Ebola virus. Francisella tularensis. Junin virus. Lassa fever virus. Mpox virus.
Any force in the environment that favors or disfavors traits is a selective agent. A force can be biological, like a predator, or physical, like temperature. Over time, populations subjected to different selective agents may become so different that they are no longer able to breed with one another.

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