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Best Practice Statement. a. Consider a duration of up to 3 weeks of antibiotic therapy after minor amputation for diabetes-related osteomyelitis of the foot and positive bone margin culture and 6 weeks for diabetes-related foot osteomyelitis without bone resection or amputation.
Acute hematogenous osteomyelitis is an infection that usually affects the growing skeleton, involving primarily the most vascularized regions of the bone. It is considered an acute process if the symptoms have lasted less than 2 weeks (2,3).
Infection usually starts in ulcerated soft tissues, but can spread contiguously to underlying bone (2). Overall, about 20% of patients with a diabetic foot infection (and over 60% of those with severe infections [3]) have underlying osteomyelitis, which dramatically increases the risk of lower-extremity amputation (4).
Agents such as cephalexin, dicloxacillin, amoxicillin-clavulanate, or clindamycin are effective choices.
The Infectious Diseases Society of America (IDSA) recommends 5 to 7 days of antibiotics (based on weak, low quality evidence) with a re-evaluation at 3 to 5 days to ensure improvement and no extension of infection (24).
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Osteomyelitis occurs in 20%60% of patients with foot ulcerations [3]. Many of these cases require hospital admission, and if the patient has a confirmed case of osteomyelitis, the risk of surgical amputation is 4 times higher than with soft tissue infection alone [4].
Bacteria or other germs may spread to a bone from infected skin, muscles, or tendons next to the bone. This may occur under a skin sore. The infection can start in another part of the body and spread to the bone through the blood. The infection can also start after bone surgery.
Diabetic foot osteomyelitis (DFO) is mostly the consequence of a soft tissue infection that spreads into the bone, involving the cortex first and then the marrow. The possible bone involvement should be suspected in all DFUs patients with infection clinical findings, in chronic wounds and in case of ulcer recurrence.

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