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Endometrial thickness is important in pregnancy. If a person wishes to become pregnant, healthcare professionals link the best chance of a full-term pregnancy with an endometrium that is neither too thin nor too thick. This optimal thickness allows the embryo to implant correctly and receive the nutrition it needs.
The root cause of endometrial hyperplasia is an imbalance between estrogen and progesterone; the condition may mean that the lining is not fully shed each month. When there is an unusual thickening of the uterine lining, it can result in what is known as endometrial hyperplasia.
Overview. Endometrial hyperplasia is a precancerous condition in which there is an irregular thickening of the uterine lining. This may cause uncomfortable symptoms for women, including heavy menstrual periods, postmenopausal bleeding, and anemia due to the excess bleeding.
Some factors such as women age, infertility etiology, drug protocol, estradiol levels, previous injuries to endometrium, were supposed as important affecting factors with endometrial growth (7-9).
[8] found that clinical pregnancy rate and live birth rate were docHubly lower when endometrial thickness was less than 8 mm than when endometrial thickness was 9 mm. In the present study, the thinnest endometrial lining for successful clinical pregnancy was 4.8 mm.
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Results. In a postmenopausal woman with vaginal bleeding, the risk of cancer is approximately 7.3% if her endometrium is thick ( 5 mm) and 0.07% if her endometrium is thin ( 5 mm). An 11-mm threshold yields a similar separation between those who are at high risk and those who are at low risk for endometrial cancer.
Endometrial hyperplasia thickens your uterine lining, causing heavy or abnormal bleeding. Atypical endometrial hyperplasia raises your risk of endometrial cancer and uterine cancer. The condition tends to occur during or after menopause. Progestin therapy can reduce your symptoms.
Conclusions: In a postmenopausal woman without vaginal bleeding, if the endometrium measures 11 mm a biopsy should be considered as the risk of cancer is 6.7%, whereas if the endometrium measures or = 11 mm a biopsy is not needed as the risk of cancer is extremely low.

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