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Opioid-induced constipation (OIC) in patients with chronic non-cancer pain 2026
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Is opioid-induced constipation permanent?
Opioid-induced dysfunction is a distressing condition that may persist indefinitely in the clinical setting. As we understand more about normal gastrointestinal (GI) physiology, we are also beginning to understand more fully how opioids cause dysfunction.
How do you treat opioid-induced constipation in patients with chronic non cancer pain?
Other therapies include naloxegol, , and naldemedine. Naloxegol and naldemedine are both approved for treatment of OIC in patients with non-cancer pain. has only been approved to treat recalcitrant cases of postoperative ileus.
How do you treat opioid syndrome?
If the person has opioid-induced constipation: Do not prescribe bulk-forming laxatives. Offer an osmotic laxative and a stimulant laxative (or docusate is an alternative which also has stool-softening properties). Consider naldemedine as an option if other laxative treatments have been ineffective.
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Related links
Peripherally acting -opioid receptor antagonists as treatment options for constipation in noncancer pain patients on chronic opioid therapy. / Pergolizzi,Read more
by KS Coyne 2014 Cited by 152 Patients treated with opioids for noncancer pain commonly endure constipation symptoms that limit their work productivity and overall health-related quality ofRead more