Proposed Chronic Migraine Treatment Trial Concept - American 2025

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Acute treatments for chronic migraine Triptans: Triptans are often a preferred treatment for migraine. They work by imitating some actions of serotonin and constricting blood vessels throughout the body, which helps reduce pain.
MedStar Health scientists participated in a recently published study of a new drug, atogepant, could help reduce the volume of migraine attacks in patients with chronic migraine. Women are three times more likely than men to have migraine headaches, which are most common in people under age 65.
Scientists havent found a cure for migraines, but theyre better at treating the symptoms. In fact, theyve made more advances in migraine treatment in the last 2 years than in the previous 30 years.
Drugs known as triptans came out on top, based on real-world data from some 278,000 migraine sufferers. If you suffer from the throbbing, intense pain set off by migraine headaches, you may well wonder which medicines are most likely to offer relief.
These new approaches open options for clinicians treating patients with particularly refractory and difficult migraines. Emerging therapies include CGRP-receptor antagonists, CGRP antibodies, a 5-HT1F receptor agonist, and new deliveries for proven treatments in intranasal form and non-invasive neuromodulation.

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The newest novel drug (approved March 9, 2023) for the treatment of migraine is Zavzpret (zavegepant) nasal spray.

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