Getting Started with UCSF Chimera - bmb uga 2025

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Chimaeras are tapered fishes with large pectoral and pelvic fins, large eyes, and two dorsal fins, the first preceded by a sharp spine. They have slender tails, from which the name ratfish, applied to some, has been derived.
UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use. Commercial users, please see Chimera commercial licensing.
Chimera command files can be created manually or by saving the Command History. Rules and tips: Lines that begin with a pound sign (#) are interpreted as comments. Multiple commands separated by semicolons (;) can be combined into a single line.
Open the AlphaFold window in the Chimera Gui via Tools Structure Prediction AlphaFold. Fetch an AlphaFold prediction from the Alphafold-EBI database by setting the Sequence input field to UniProt identifier and provide the Uniprot ID of the protein of interest, e.g. INSRHUMAN.
0:34 2:23 We click into it. Then it will open that protein structure for us.MoreWe click into it. Then it will open that protein structure for us.
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Tools Viewing ControlsSide View. To rotate the structure click and move the mouse. To move a structure, click and drag the middle mouse button.
Each Chimera window or tool can be moved to a convenient location by clicking its top bar and dragging. Now open a structure. Choose FileFetch by ID and type 1zik in the PDB ID field. The structure will appear in the main graphics window; it is a leucine zipper formed by two peptides.

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