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All human beings are 99.9 percent identical in their genetic makeup. Differences in the remaining 0.1 percent hold important clues about the causes of diseases.
You can think of the set of instructions that make you human as a book. That book would be called your genome. What is a gene? ( An analogy) A gene can be compared to a single sentence in the instruction manual.
The book analogy is a popular way of explaining genome changes. If the human genome is a book, the benchmark will help scientists better detect large chapters that are missing (deleted chapters) or not in the original (inserted chapters).
To return to our library analogy, the human genome is like a stack of 20,000 to 25,000 books, each on average about 1,500 letters long. Each book represents a gene. But unlike most libraries only 1% to 2% of the shelf space contains books.
Scientists can estimate these relationships by studying the organisms DNA sequences. As the organisms evolve and diverge, their DNA sequences accumulate mutations. Scientists compare these mutations using sequence alignments to reconstruct evolutionary history.
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A tool that has revolutionized, and continues to revolutionize, phylogenetic analysis is DNA sequencing. With DNA sequencing, rather than using physical or behavioral features of organisms to build trees, we can instead compare the sequences of their orthologous (evolutionarily related) genes or proteins.
Gene Genes are instructions that tell our bodies what to do or make, like what color eyes we have. Genes are the books in our library (the body). DNA-DNA is the alphabet used to make words in our books. The DNA alphabet has only 4 letters A, T, C, and G.
A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.

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