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CSF forms at a rate of about 0.30.4 mL/min; translating to 18-25 mL/hour and 430530 mL/day. [1] The classic thought is that CSF flows due to the forces generated by cardiac pulsations and pulmonary respiration.
CSF provides hydromechanical protection of the neuroaxis through two mechanisms. First, CSF acts as a shock absorber, cushioning the brain against the skull. Second, CSF allows the brain and spinal cord to become buoyant, reducing the effective weight of the brain from its normal 1,500 grams to a much lesser 50 grams.
Normal values typically range as follows: Pressure: 70 to 180 mm H2O. Appearance: clear, colorless. CSF total protein: 15 to 60 mg/100 mL (0.15 to 0.6 g/L)

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A very high CSF protein concentration (greater than 500 mg/dL) is an infrequent finding but can occur with bacterial meningitis, subarachnoid hemorrhage, or spinal‐subarachnoid block.
Borderline high pressure readings are between 200-250mm/H2O. Anything above 250mm/H2O is considered a high pressure reading. For young children: Anything above 200 mm/H2O is considered a high pressure reading.
The diagnosis is also confirmed by detecting a high spinal CSF pressure reading, usually greater than 250 mmH2O or 25 cmH2O (200-250 mmH2O or 20-25 cmH2O is considered borderline high) and normal laboratory and imaging studies including CT scans and MRIs.
CSF is produced at a rate of around 500 ml/day; there are estimates that there is approximately 125 mL to 150 mL of CSF in the body at any given time. Depending on the rate of production and absorption (which varies individually), the supply of CSF can be replaced about every 7.5 hours.
Elevated CSF protein (30 mg/dL) is a nonspecific finding that is encountered in various neurologic disorders. Several common etiologies should be considered: Infection: Tuberculous meningitis, acute bacterial meningitis (pneumococcal, meningococcal, Haemophilus influenzae), syphilitic or viral meningitis, encephalitis.

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