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NGS-based tumor analysis can provide more comprehensive assessments than standard clinical molecular/cytogenetic testing and could eliminate the time delays23 inherent to performing sequential assays (Table 1), particularly for cases with diagnostic uncertainty or for which tumor tissue is limited (small biopsies from
NCI researchers use molecular and genomic profiling to study the causes of cancer. This enables a better understanding of how normal cells transform into cancer cells, and to pinpoint internal processes and external exposures associated with specific molecular or genomic subtypes of cancer.
The St. Jude Childrens Research HospitalWashington University Pediatric Cancer Genome Project (PCGP) is participating in the international effort to identify somatic mutations that drive cancer.
Cancer genomics is the study of the totality of DNA sequence and gene expression differences between tumour cells and normal host cells.
Whereas molecular biology focuses on the impact of individual genes on the cancer state, functional genomics assesses the comprehensive genetic alterations in a cancer cell and seeks to integrate the dynamic changes in these networks so that cancer phenotypes can be explained.
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This gives insight into the exact nature and genomic changes that are causing an individuals cancer and can: Improve diagnosis. using increasingly advanced DNA-deciphering genomics technologies. Help clinicians select the most effective treatments. Show which patients are likely to benefit from clinical trials.
Cancer genomics research also contributes to precision medicine by defining cancer types and subtypes based on their genetics. This molecular taxonomy of cancer can provide patients with a more precise diagnosis, and therefore a more personalized treatment strategy.
Genetic testing for cancer can be done in two ways: testing cancer cells themselves or testing healthy cells, usually from the blood. Testing cancer cells shows which mutations are present in a cancer, while testing healthy cells may show if your child has a predisposition that could explain why the cancer developed.

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