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The widely recommended 5As strategy for brief smoking cessation includes five tasks: Ask, Advise, Assess, Assist, and Arrange.
A randomized clinical trial (RCT) demonstrated that opt-out treatment achieved higher verified quit rates (22%) than opt-in treatment (16%) 1 month after randomization. When people who smoke have a higher desire to quit before treatment, they have a higher rate of smoking cessation.
The detection of exposure to tobacco smoke by measurement of cotinine is the preferred method, as levels of nicotine are not considered a valid marker of smoking status due to its relatively short half-life. Since cotinine diffuses easily from blood into saliva, salivary and serum cotinine levels are highly correlated.
A new study led by researchers at The University of Kansas Cancer Center found that an opt-out approach, where people who smoke are provided with tobacco cessation medications and counseling unless they decline, significantly increases quit rates.
There are three pharmacotherapies currently licensed widely throughout the world for smoking cessation: nicotine replacement therapy (NRT), bupropion and varenicline.
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