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Institutional review boards (IRBs) have the federally mandated responsibility to review research involving human subjects to ensure that a proposed protocol meets the appropriate ethical guidelines before subjects may be enrolled in the study.
The Protection of Human Subjects in Medical Experimentation Act (sections 2417024179.5) describes the informed-consent process and requires that the experimental subjects bill of rights be provided to all research subjects in medical experiments.
An IRB (Institutional Review Board) must review all human subjects research activities covered by the HHS regulations. Non-exempt research undergoes either Expedited (subcommittee) review or Full Board review. Protocols cannot be expedited if the research involves more than minimal risk.
IRBs are charged with providing an independent evaluation that proposed research is ethically acceptable, checking clinical investigators potential biases, and evaluating compliance with regulations and laws designed to protect human subjects.
To accomplish this purpose, IRBs use a group process to review research protocols and related materials (e.g., informed consent documents and investigator brochures) to ensure protection of the rights and welfare of human subjects of research.
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The Institutional Review Board (IRB) is an administrative body established to protect the rights and welfare of human research subjects recruited to participate in research activities conducted under the auspices of the institution with which it is affiliated.
Federal Regulation 45 CFR 46 Protection of Human Subjects, referred to as the Common Rule, is an anchor regulatory text on which investigators and IRBs rely and must comply to protect human subjects in research.
Under FDA regulations, an IRB is an appropriately constituted group that has been formally designated to review and monitor biomedical research involving human subjects. In ance with FDA regulations, an IRB has the authority to approve, require modifications in (to secure approval), or disapprove research.

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