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What is excitation-contraction coupling in smooth muscles?

Excitation-contraction coupling involves the transformation of depolarizing events in the sarcolemma into the initiation of mechanical shortening of the myofibrils within the myofiber by calcium ions released from the terminal cisternae of the sarcoplasmic reticulum (SR).

What is the difference between EC coupling in smooth and skeletal muscle?

The difference of excitation-contraction coupling between the skeletal and smooth muscle is that the smooth muscle has other sources of calcium such as extracellular and intracellular sources.

What is the sequence of events in excitation contraction coupling of smooth muscle?

The EC-coupling cycle involves the following sequence of events: (1) depolarization of the plasma membrane and its membrane invaginations (the t-tubular system) by an action potential; (2) transduction of the depolarization signal to the sarcoplasmic reticulum (SR) membrane; (3) activation of Ca2+ release from the SR

What is excitation-contraction coupling in the nervous system?

Excitation-contraction coupling (ECC) is an essential process in muscle physiology, responsible for linking electrical signals from the somatic nervous system (action potentials) to mechanical muscle contractions (Sandow 1952).

What happens during excitation contraction coupling?

First coined by Alexander Sandow in 1952, the term excitationcontraction coupling (ECC) describes the rapid communication between electrical events occurring in the plasma membrane of skeletal muscle fibres and Ca2+ release from the SR, which leads to contraction.

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How does contraction occur in smooth muscle?

Smooth muscle contraction depends on calcium influx. Calcium increases within the smooth muscle cell through two different processes. First, depolarization, hormones, or neurotransmitters cause calcium to enter the cell through L-type channels located in the caveolae of the membrane.

How is contraction regulated in smooth muscle?

Smooth-muscle contraction is regulated by two systems, which operate indirectly and slowly via covalent protein modification. One involves phosphorylation of the myosin regulatory light-chain, the other phosphorylation of caldesmon on the actin filaments. Both are dependent on the Ca2+-binding CM.

What is the muscle contraction coupling process?

First coined by Alexander Sandow in 1952, the term excitationcontraction coupling (ECC) describes the rapid communication between electrical events occurring in the plasma membrane of skeletal muscle fibres and Ca2+ release from the SR, which leads to contraction.

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