Mr1b 2026

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Mr1 major histocompatibility complex, class I-related [Mus musculus (house mouse)] - Gene - NCBI. The . gov means its official.
In humans and rodents it is expressed in a broad range of cell types, both haematopoietic and non-haematopoietic, although cell surface expression has been difficult to detect. Although MR1 trafficking shares features with both the MHC class I and MHC class II pathways, it is distinct.
Summaries for MR1 Gene Diseases associated with MR1 include Immune Deficiency Disease and Hemochromatosis, Type 1.

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Structure. MR1, like other MHC class I molecules, is composed of 1, 2 and 3 domains. 1 and 2 interact and together bind the antigen. The ligand binding pocket is small and contains aromatic and basic residues.
The other genes that map within the MHC include some that encode complement components (for example, C2, C4, and factor B) and some that encode cytokinesfor example, tumor necrosis factor- (TNF-) and lymphotoxin (TNF-)all of which have important functions in immunity.
major histocompatibility complex (MHC), group of genes that code for proteins found on the surfaces of cells that help the immune system recognize foreign substances. MHC proteins are found in all higher vertebrates. In human beings the complex is also called the human leukocyte antigen (HLA) system.
Non-classical MHC class I molecules constitute another means whereby malignant cells escape immunosurveillance. Indeed, these molecules inhibit the activity of the immune system by binding to inhibitory receptors expressed by effector cells, hence suppressing their functions or inducing their apoptotic demise.
MR1 is a ubiquitously expressed non-polymorphic MHC class I-like molecule, which presents a family of bacteria-derived metabolites to MAIT cells. MR1 is characterized by three domains, a transmembrane domain, and a cytoplasmic tail.

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