HPRP Substantial Amendment draft6 May 9 2025

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Substantive Amendment means an amendment other than an Editorial Amendment. It changes the purpose, scope or substantive content of the Policy Instrument.
substantial amendment is for the HOME-ARP Allocation Plan. A preference permits an eligible QP applicant to be selected for assistance before another eligible qualifying applicant. A limitation excludes certain QPs or subpopulations of QPs from eligibility for a project or activity.
An amendment is considered as substantial if the modification has a significant impact on: - Security or physical or mental integrity of the subject. - Scientific value of the trial. - Organization and execution manner of the trial.
Amendments to the trial are regarded as substantial where they are likely to have a significant impact on: the safety or physical or mental integrity of the subjects, or the scientific value of the trial, or the conduct or management of the trial, or the quality or safety of any IMP used in the trial.
property rights of affected owners are protected under the Fourteenth Amendment and the Takings Clause of the Fifth Amendment of the U.S. Constitution. 3 These provisions apply regardless of the personal status or income of the affected private owner.