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What is the medicinal use of pokeweed?

Pokeweed has many purported benefits but little science to back them up. In traditional folk medicine, pokeweed stimulates the bowels and induces vomiting. In homeopathic medicine, pokeweed is used to treat tonsillitis. It is also used to treat psoriasis and eczema and suppress inflammatory immune responses.

Is pokeweed antiviral?

Pokeweed synthesizes PAP, an N-glycosidase and RIP that depurinates the conserved -sarcin loop of large rRNAs (Endo et al., 1988). PAP exhibits antiviral activity against diverse plant and animal viruses.

Which is a naturally produced antiviral protein in humans?

Zinc-finger antiviral proteins (ZAP) are produced by both human and animal cells to stop the spread of viruses by targeting viral mRNA, which can lead to innate immune mechanisms against infections.

What is an example of an antiviral protein?

Interferons are antiviral proteins synthesized by many kinds of somatic cells in response to viral infection. Specific antigens and T and B lymphocytes stimulants are also able to induce the production of interferon but only in immunocompetent cells.

What is pokeweed antiviral protein?

Pokeweed antiviral protein (PAP) from Phytolacca americana is a ribosome inactivating protein (RIP) and is an RNA N-glycosidase that removes specific purine residues from the sarcin/ricin (S/R) loop of large rRNA, arresting protein synthesis at the translocation step.