Autonomic Dysreflexia in Spinal Cord Injury: Overview 2025

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Briefly, autonomic dysreflexia develops in individuals with a neurologic level of SCI at or above the sixth thoracic vertebral level (T6). Autonomic dysreflexia causes an imbalanced reflex sympathetic discharge, leading to potentially life-threatening hypertension.
Injury that affects upper motor neurons produces autonomic dysreflexia (AD). Therefore, individuals with spinal cord injury in the cervical or thoracic regions of the spinal cord (above T6) are at risk for AD because this is the location of the upper motor neuron axons or arms.
If you are experiencing an episode of Autonomic Dysreflexia First, you should get into a sitting position or elevate your head as much as possible. Changing position can drop your blood pressure. Since bladder issues are the most common cause of AD, you or a caregiver should check your bladder.
Autonomic dysreflexia is a condition that emerges after a spinal cord injury, usually when the damage has occurred above the T6 level. The higher the level of the spinal cord injury, the greater the risk, with up to 90% of patients with cervical spinal or high-thoracic spinal cord injury being susceptible.
Traditional anti-spastic medications include baclofen, tizanidine, BoNT, benzodiazepine, clonidine, dantrolene, and cannabis, whereas compounds to alleviate autonomic dysreflexia include anti-hypertensive nitrates, nifedipine, and adrenergic blockers.
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T6-T8 nerves: Influence the chest and upper abdominal muscles. They play a role in deeper breathing by engaging the diaphragm and upper abdominal muscles, contributing to core stability and balance. This section also helps with posture and protects the spine during movement.

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