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Perceptions of Pediatric Clinical Research Among African 2026

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Four major barriers to participation in clinical trials were identified: lack of awareness about trials, economic factors, communication issues, and mistrust.
A number of barrier themes were identified in the study, including mistrust of researchers and the health care system, fear related to research participation, inadequate information about research and opportunities to participate, inconvenience, questionable reputation of the researcher or research institution, and
Of the 612 articles, 486 (79.4%) reported participant race and 338 (55.2%) reported participant ethnicity. From 2011 to 2020, relative rates of reporting of participant race increased by 7.9% per year (95% CI, 0.2%-16.3% per year) and reporting of ethnicity increased by 11.4% per year (95% CI, 4.8%-18.4% per year).
Issues of trust, physician perceptions and biases, and structural issues such as access to health care might factor into the low levels of minority participation in therapeutic clinical trials.
Practical barriers, such as lack of transportation, lack of health insurance, financial constraints, lack of family support, trial duration, and high frequency of office visits also have been found to deter patients from participating in clinical research [3, 11, 12, 14, 17].

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Barriers to participation in AD clinical trials for Black populations include mistrust, lack of awareness, the need for a study partner, and participant burden.

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