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In other words, an LAR is only necessary when an adults mental capacity is impaired, rendering them unable to provide informed consent. This is different from a parent or guardian, who provides permission for a child to participate in research.
Depending on individual circumstances, a guardian may have physical custody of a child, decision-making custody, or both. In some cases, a parent may retain full or partial physical custody while a guardian has legal custody; for example, in cases of a parent with cognitive impairment.
A legally authorized representative is an individual who, under law, has the ability to act on behalf of another person (such as a minor study participant). The LAR may be a parent, grandparent, caregiver who has the legal authority to grant consent on behalf of another who has been invited to participate in research.
A guardianship/conservatorship is no longer effective after death, and the guardian/conservator simply has final accounting type reports to submit to the Court. A personal representative is the person who handles the probate of the subjects estate after his/her death.
Legally Authorized Representative (LAR): An individual or judicial or other body authorized under applicable law to consent on behalf of a prospective subject to the subjects participation in the procedures involved in the research.
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A Legally authorized representative (LAR) is an individual or judicial or other body authorized under applicable law to make decisions on behalf of another individual. LARs may, for example, provide consent on behalf of a prospective subject to the subjects participation in research.
An Authorized Representative is an individual with legal authority to bind the government entity (e.g., the Chief Executive Officer of the government entity). An Authorized Representative must sign the Acceptance of Award terms for it to be valid.

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