Encephalitis questionnaire 2025

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Diagnostic criteria for encephalitis as proposed by the International Encephalitis Consortium2: an altered mental status lasting for 24 h or more with no alternative cause identified (1395 complete cases); fever (38 C) within 72 h before or after presentation (1434 complete cases); seizures not attributable to a pre-
Tests for encephalitis can include: Neuroimaging, such as a brain MRI or CT scan. A lumbar puncture (spinal tap) to check for signs of infection in the brain or spinal cord. Electroencephalogram (EEG) to look for seizures or specific patterns of electrical activity in the brain.
Spinal tap, known as a lumbar puncture. Changes in this fluid can point to infection and inflammation in the brain. Sometimes samples of CSF can be tested to identify the cause. This may include testing for infection or the presence of antibodies associated with autoimmune encephalitis.
Magnetic resonance imaging is the gold standard technique for brain imaging in encephalitis,12 and is abnormal in 90% of cases of HSV encephalitis,4 but may be normal or subtly abnormal in autoimmune encephalitis (Fig 2).
To diagnose encephalitis, a member of your healthcare team does a physical exam and takes your medical history. Your healthcare professional might then recommend: Brain imaging. MRI or CT images can reveal any swelling of the brain or another condition that might be causing your symptoms, such as a tumor.

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Antibody testing should be performed in both CSF and serum to avoid false-negative and false-positive results. For example, testing for NMDAR antibodies typically has higher sensitivity in CSF compared with serum, with up to 15% of patients having negative serum results.
Brain scans A scan of the brain can help show whether you have encephalitis or another problem such as a stroke, brain tumour or brain aneurysm (a swelling in an artery). The 2 main types of scan used are: a CT scan. an MRI scan.

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