Appendix C--Transportation of Infectious Substances - cdc 2025

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The document outlines the regulations and requirements for the transportation of infectious substances, which are materials known to contain pathogens that can cause disease in humans or animals. It details the classification of these substances into Category A and Category B, each with specific packaging and labeling requirements to ensure safety during transport. The document also emphasizes the importance of compliance with various regulatory bodies, including the Department of Transportation (DOT), CDC, USDA, and international organizations, to prevent exposure risks and ensure public health safety.
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Section 173.134(b) of the HMR contains a list of scenario-based exceptions in which some materials are not subject to the requirements for Division 6.2 infectious substances. If a material meets all the conditions of any scenario, it is not regulated.
Category B: An infectious substance that does not meet the criteria for inclusion in Category A. A mailpiece known or suspected to contain a Category B infectious substance is mailable as described in 346 and DMM 601.10. 17. Proper Shipping Name and ID Number Biological substance, Category B, UN3373.
Division 6.2 Infectious Substance: A material known or reasonably expected to contain a pathogen, such as bacteria, viruses, rickettsiae, parasites, fungi or prions, that can cause disease in humans or animals.
Category A infectious substances are transported in a form that poses the highest risk of infection during transportation. Category A consists of Virus and Bacteria listed in the first four Tables in Appendix 3 to Part 2 of the TDG Regulations.
Infectious substance definition: The U.S. Department of Transportation (DOT) and the International Air Transportation Association (IATA) define an infectious substance as a material known or reasonably expected to contain a microorganism or infectious particle that can cause disease in humans or animals.

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Materials that qualify as infectious substances include cultures, patient specimens, biological products, medical or clinical wastes, and medical devices or equipment. [See World Health Organization. (2021, February 25).
A Division 6.2 infectious substance is a material known or reasonably expected to contain a pathogen. A pathogen is a micro-organism (including bacteria, viruses, rickettsia, parasites, fungi) or other agent, such as a proteinaceous infectious particle (prion), that can cause disease in humans or animals.

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