Smallpox Case Investigation Supplementary ( Form 1B ) Page 1 of 2 - www2 cdc 2025

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The laboratory criteria for diagnosis are: Polymerase chain reaction (PCR) identification of variola DNA in a clinical specimen, OR. Isolation of smallpox (variola) virus from a clinical specimen (WHO Smallpox Reference Laboratory or laboratory with appropriate reference capabilities) with variola PCR confirmation.
Despite these ongoing arguments, live samples of the smallpox virus are still housed at two locations. One laboratory is in Russias State Research Center of Virology, located in the city of Koltsovo in Siberia. The other samples are kept at the U.S. Centers for Disease Control and Prevention in Atlanta.
1980. The World Health Organization (WHO) declares smallpox eliminated worldwide due to vaccinations. Smallpox vaccination ends. Before the smallpox vaccine, smallpox had been considered one of the deadliest infectious diseases.
The eradication of smallpox from the world was certified by the Global Commission, an independent panel of scientists drawn from 19 nations, in December 1979 at WHO Headquarters, Geneva.
Thanks to the success of vaccination, smallpox was eradicated, and no cases of naturally occurring smallpox have happened since 1977. The last natural outbreak of smallpox in the United States occurred in 1949. The World Health Assembly declared smallpox eradicated in 1980.
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In addition, the vaccine was proven to prevent or substantially lessen infection when given within a few days after a person was exposed to the variola virus. Routine smallpox vaccination among the American public stopped in 1972 after the disease was eradicated in the United States.

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