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Rabies affects the central nervous system (the brain and spinal cord). Without appropriate medical care, rabies causes brain disease and death. Once symptoms of rabies appear, the disease is nearly always fatal. For this reason, preventing animal bites and receiving prompt medical care is especially important.
The rabies post-exposure risk assessment tool is designed to determine if post-exposure prophylaxis (PEP) is needed for an individual who was potentially exposed to rabies from contact with an animal. PEP is a series of shots, typically given in the arm similar to a flu shot, given as prevention of rabies.
Most human deaths from rabies happen in Asia and Africa, where the disease is mainly spread by dogs. There is also a high risk of rabies in some parts of: the Caribbean. South America.
Rabies virus infects the central nervous system. Symptoms may occur from days to years after exposure to the virus and include delirium (confusion), abnormal behavior, hallucinations, hydrophobia (fear of water), and insomnia (difficulty sleeping), which precede coma and death.
People are usually infected following a deep bite or scratch from an animal with rabies, which is, in 99% of the cases, a dog. Transmission can also occur if saliva of infected animals comes into direct contact with mucosa (e.g. eyes or mouth) or fresh skin wounds.

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Once clinical signs of rabies appear, the disease is nearly always fatal, and treatment is typically supportive. Less than 20 cases of human survival from clinical rabies have been documented. Only a few survivors had no history of pre- or postexposure prophylaxis.
Rabies is a viral zoonotic disease that causes progressive and fatal inflammation of the brain and spinal cord. Clinically, it has two forms: Furious rabies characterized by hyperactivity and hallucinations. Paralytic rabies characterized by paralysis and coma.
The rabies virus infects the central nervous system. If a person does not receive the appropriate medical care after a potential rabies exposure, the virus can cause disease in the brain, ultimately resulting in death.

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