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progressiveMauve builds up genome alignments progressively ing to a guide tree. The guide tree is computed based on an estimate of the shared gene content among each pair of input genomes.
The Mauve genome alignment procedure results in a global alignment of each locally collinear block that has sequence elements conserved among all the genomes under study. Nucleotides in any given genome are aligned only once to other genomes, suggesting orthology among aligned residues.
Mauve has been applied to align nine enterobacterial genomes and to determine global rearrangement structure in three mammalian genomes. We have evaluated the quality of Mauve alignments and drawn comparison to other methods through extensive simulations of genome evolution.
The Mauve genome alignment procedure results in a global alignment of each locally collinear block that has sequence elements conserved among all the genomes under study. Nucleotides in any given genome are aligned only once to other genomes, suggesting orthology among aligned residues.
the plugin by downloading the gplugin file and dragging it in to Geneious or use the plugin manager in Geneious (under Tools - Plugins in the menu). Once installed, run the plugin by selecting two or more nucleotide sequences and clicking on Align/Assemble - Align Whole Genomes in the toolbar.
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The Mauve Contig Mover (MCM) algorithm will align a draft genome to a reference sequence, ordering the contigs in the draft genome ing the their position along the reference genome.
Mauve is a system for constructing multiple genome alignments in the presence of large-scale evolutionary events such as rearrangement and inversion. Multiple genome alignments provide a basis for research into comparative genomics and the study of genome-wide evolutionary dynamics.

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