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B. Background and Significance Specify the problem of the study and provide a more detailed elaboration of the research purpose. State the rationale of your research proposal and explain, in an engaging way, why it is worthwhile to conduct. Present the core problems or issues that will be addressed.
It should demonstrate how each cost is necessary, reasonable, and allowable for your project. If you fail to justify your costs, you risk losing the trust and confidence of your reviewers and funders.
JUSTIFICATION OF PROJECT ALIGNMENT TO RESEARCH PRIORITIES Explain how your proposed project aligns to the selected research priority/priorities. If your project aligns to multiple priority areas, provide additional justification of the alignment to those areas in this section as well.
Purpose: The Significance section should explain the importance of the problem or describe the critical barrier to progress in the field that is being addressed. Explain how the proposed research project will improve scientific knowledge, technical capability, and/or clinical practice in one or more broad fields.
Writing the Specific Aims A good way to start is with a sentence that states your projects goals. In some cases, you may want to explain why you did not take an alternative route. State your hypothesis (if relevant) and briefly describe your aims and how they build on rigorous prior and preliminary studies.
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