VistaSeq - Sample Report - Variant of Uncertain Significance (PDF) 2025

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A variation in a genetic sequence for which the association with disease risk is unclear. Also called unclassified variant, variant of uncertain significance, and variant of unknown significance.
Definition. When analysis of a patients genome identifies a variant, but it is unclear whether that variant is actually connected to a health condition, the finding is called a variant of uncertain significance (abbreviated VUS).
Somatic cancer panel testing often detects variants in cancer cells that have unknown or unclear effects on the cancer cells. These are called variants of uncertain significance, or VUS.
However, as part of genetic testing, other types of variants are often found, including those called variants of uncertain significances (VUS). Benign or Likely Benign These are harmless variants. They are not expected to impact a persons health.
A change in a genes DNA sequence that has an unknown effect on a persons health. There is usually not enough information about a VUS to know whether it increases a persons risk of developing a disease, such as cancer.
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If the classification of the variant is as a VUS, it means that, at the time of interpretation, there was not sufficient evidence to determine if the variant is related to disease or not. It might be that the variant in question is rare, but has not been identified in affected individuals.

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