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VistaSeq - Sample Report - Variant of Uncertain Significance (PDF)

VistaSeq - Sample Report - Variant of Uncertain Significance (PDF) 2025

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The document is a sample report for the VistaSeq℠ Hereditary Cancer Panel, detailing genetic testing results for a female patient. It indicates the detection of a heterozygous variant of uncertain significance in the PMS2 gene, which is associated with Lynch syndrome and increased cancer risk. The report recommends genetic counseling to discuss the implications of these findings. It also outlines the methodology used for testing and provides information on additional genes included in the panel.

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Click ‘Get Form’ to open the VistaSeq - Sample Report in the editor.
Begin by entering the Patient Details. Fill in the patient's date of birth, age, gender, and patient ID in the designated fields.
Next, move to Specimen Details. Input the specimen ID, date collected, date reported, and specimen type as indicated.
In Client Details, provide the account number and ordering physician's name along with their address and contact information.
Review the Results and Interpretation section carefully. Ensure that any detected variants are accurately noted.
For recommendations regarding genetic counseling, make sure to include any necessary contact information for follow-up.

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What does VUS mean?

A variation in a genetic sequence for which the association with disease risk is unclear. Also called unclassified variant, variant of uncertain significance, and variant of unknown significance.

What is variant of uncertain significance analysis?

Definition. When analysis of a patients genome identifies a variant, but it is unclear whether that variant is actually connected to a health condition, the finding is called a variant of uncertain significance (abbreviated VUS).

What is VUS in cancer?

Somatic cancer panel testing often detects variants in cancer cells that have unknown or unclear effects on the cancer cells. These are called variants of uncertain significance, or VUS.

Should I worry about VUS in genetic testing?

However, as part of genetic testing, other types of variants are often found, including those called variants of uncertain significances (VUS). Benign or Likely Benign These are harmless variants. They are not expected to impact a persons health.

What is VUS in oncology?

A change in a genes DNA sequence that has an unknown effect on a persons health. There is usually not enough information about a VUS to know whether it increases a persons risk of developing a disease, such as cancer.

What does it mean if a result came back as a variant of uncertain clinical significance?

If the classification of the variant is as a VUS, it means that, at the time of interpretation, there was not sufficient evidence to determine if the variant is related to disease or not. It might be that the variant in question is rare, but has not been identified in affected individuals.