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Conditions known to decrease Coumadin effect and decrease INR include: Hypothyroidism. High vitamin K intake. Nephrotic syndrome.
Avoid eating too much of the same thing (for example, a whole plate of broccoli or a big bowl of salad greens). Foods high in vitamin K include kale, collards, broccoli, spinach, and other green leafy vegetables. Cranberry juice and alcohol may also affect Coumadin levels so limit your intake of these.
COUMADIN and other coumarin anticoagulants act by inhibiting the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S.
Coumadin (generiC name: Warfarin) and Other drugs frOm the same Class Of antiCOagulant mediCines.
How does Coumadin work? Your blood contains clotting factors that act to form a blood clot when you are bleeding. Vitamin-K is needed for these factors to be made. Coumadin works by blocking the production of these Vitamin-K dependent clotting factors.
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Foods high in vitamin K can affect the way Coumadin works in your body. The more vitamin K rich foods you eat, the lower the levels of Coumadin in your body. This means your INR (International Normalized Ratio) will be lower and you will be more likely to form a blood clot.
Common drugs that can interact with warfarin include: Aspirin or aspirin-containing products. Acetaminophen (Tylenol, others) or acetaminophen-containing products. Antacids or laxatives. Many antibiotics. Antifungal medications, such as fluconazole (Diflucan) Cold or allergy medicines.

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