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Belimumab is a fully human monoclonal antibody for the treatment of autoimmune disorders that is being developed by Human Genome Sciences and GlaxoSmithKline. Two pivotal phase III trials in systemic lupus erythematosus have been concluded with the primary endpoints being met in both studies.
Belimumab helps treat mild to moderate lupus that affects the skin, joints, and other organs. It is not a chemotherapy drug.
Belimumab is used with other medications to treat certain types of systemic lupus erythematosus (SLE or lupus; an autoimmune disease in which the immune system attacks healthy parts of the body such as joints, skin, blood vessels, and organs) in adults and children 5 years of age and older.
(belimumab) is a biologic therapy Biologic therapy: A treatment derived from a living cell or tissue. , not a steroid Steroid: Treatment to reduce swelling, pain, and other symptoms of inflammation. .
Belimumab is in a class of medications called monoclonal antibodies. It works by blocking the activity of a certain protein in people with SLE and lupus nephritis.
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Belimumab is also used with other medications to treat lupus nephritis (an autoimmune disease in which the immune system attacks the kidneys) in adults. Belimumab is in a class of medications called monoclonal antibodies. It works by blocking the activity of a certain protein in people with SLE and lupus nephritis.
Answer: Belimumab is a recombinant, fully human, monoclonal antibody directed against the cytokine BLyS, also known as B-cell activating factor (BAFF). [1] It belongs to the tumor necrosis factor (TNF) superfamily and plays a central role in B-cell survival and function.
Belimumab helps treat mild to moderate lupus that affects the skin, joints, and other organs. It is not a chemotherapy drug.
In lupus, the immune system produces harmful antibodies that attack the bodys own tissues. Belimumab works by reducing the activity of a type of white blood cell called B-cells that produce the antibodies. This reduces the inflammation that causes the symptoms of lupus.
In the prelicensure studies there were no reports of clinically apparent liver injury attributed to belimumab and, since its approval and more wide scale use, there have been no case reports of liver injury with jaundice linked to belimumab therapy.

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