UKALL 2003 Version 7 - University of Oxford - ctsu ox ac-2025

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The document outlines the UKALL 2003 trial protocol, a national randomized trial for children and young adults with Acute Lymphoblastic Leukaemia (ALL). It details the study's objectives, including testing MRD-based risk stratification to optimize therapy while minimizing toxicity. The document includes treatment regimens, eligibility criteria, randomization processes, safety measures, and ethical considerations. It emphasizes the importance of monitoring minimal residual disease (MRD) to tailor treatment intensity based on individual patient responses. Additionally, it discusses potential risks associated with treatments and provides guidelines for managing adverse events.

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