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Turns out the answer is yes: Low homocysteine levels do indeed have disease correlations. For example, low homocysteine has been shown to have a strong association with peripheral neuropathy. A surprising 41% of patients with idiopathic peripheral neuropathy have hypohomocysteinemia.
Signs and symptoms that your homocysteine might be too low? Chronic gut infections. Inflammatory conditions such as endometriosis. Dizziness. Low blood pressure. Fatigue. Nausea. Brain fog. Headaches.
How Can You Lower Homocysteine Levels? Elevated homocysteine levels can be lowered. We know that folic acid, vitamin B6, and vitamin B12 are all involved in breaking down homocysteine in the blood. Therefore, increasing your intake of folic acid and B vitamins may lower your homocysteine level.
Extremely low levels (four or five range), known as hypohomocystemia, means that the body is not converting enough methionine into cysteine. It also could mean the body isn't producing enough glutathione, taurine, or sulfate\u2014all of which are necessary for detoxification pathways.
One study found that within three weeks, homocysteine levels could be reduced by 17% using folate alone, 19% using B12 alone, 57% using folate and B12, and 60% using folate, B12 and B6 (86). Another study found that combining B6 and folate reduces homocysteine 32% within five weeks (85).
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Elevated homocysteine levels can be lowered. We know that folic acid, vitamin B6, and vitamin B12 are all involved in breaking down homocysteine in the blood. Therefore, increasing your intake of folic acid and B vitamins may lower your homocysteine level.
Most people who have a high homocysteine level don't get enough folate (also called folic acid), vitamin B6, or vitamin B12 in their diet. Replacing these vitamins often helps return the homocysteine level to normal.
In a healthy person, homocysteine levels are around five to 15 micromoles per liter (mcmol/L). Nearly all that homocysteine converts to other proteins. If you have more than 50 mcmol/L, the excess homocysteine may damage the lining of your arteries (blood vessels that carry oxygen-rich blood throughout your body).
Low homocysteine usually means low levels of glutathiones as well, which are oxidative detoxifiers. There's a fine line between too high and too low. If the body has too little, it's open to more oxidative damage. If the body has too much, there can be vascular damage and plaque.
What Are the Risks for Someone With Elevated Homocysteine Levels? An elevated homocysteine level is associated with an increased risk for developing atherosclerosis, which can in turn lead to coronary artery disease (CAD), heart attack, and stroke (Table 2).

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