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many factors influence the therapeutic efficacy of a drug including pharmacokinetics a quantifiable measure of how the body affects the drug and pharmacodynamics how the drug affects the body pharmacokinetics is a multi-step process that includes absorption or the movement of the drug into the bloodstream distribution or the movement of the drug through the blood and various tissues of the body such as brain tissue fat and muscle metabolism or the chemical alteration of the drug by the body and excretion or the elimination of the drug by the body this four-step process is referred to by the acronym add me during distribution of certain drugs proteins present in the bloodstream such as serum albumin bind the drug and render it inaccessible to its Target effective dose concentration is a measure of Unbound drug present in the bloodstream thus pharmacokinetics determines factors within the body that dictate when and how much Unbound drug docHubes its Target site after Administration pharma
