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Death by drug overdose has been on the rise in the US, with a 2.2-fold increase from 2002 to 2015. But what is the most dangerous drug in the world? [Illustrated by Kurzgesagt.] If were simply talking about the most lethal substances, scientists use something called the median lethal dose or LD50 which measures how much of a substance is required to kill half the members of a tested population. So something like coffee requires around 13g to kill a 70kg person, while the venom of an Inland Taipan snake requires much less, with only 0.00175g. Using this method, the most deadly substance on Earth? Botulinum Toxinor Botox. Oral ingestion would require only 0.00000007g to kill a 70kg person. However, most dangerous doesnt always mean most lethal. In the UK, a group of experts decided to look at how much harm the most common recreational drugs cause using 16 parameters, including types of physical, psychological and social harm. For example, a drug may cause physical damage but
