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Heart failure occurs when your heart is unable to pump enough blood to meet your body's needs. This can be due to weak or damaged ventricular walls, or stiff and thickened walls that prevent proper blood flow. Left-sided heart failure results in fatigue and shortness of breath, as well as increased pressure in blood vessels, leading to fluid buildup in the lungs. Right-sided heart failure causes blood to pool in the veins, resulting in edema throughout the body.