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and so what I did to make Locker was I took a trimer made it into a single chain so now itamp;#39;s just one single scaffold the key binds to that same interface right so the key unlocks the latch from the cage itamp;#39;s almost like a biological light switch when itamp;#39;s off its whatever function itamp;#39;s tied to is inactive but then when you switch it on at the activator youamp;#39;re activating or turning on whatever function itamp;#39;s programmed to turn on control is really the the main selling point of Locker in this in these kind of applications because itamp;#39;s so modular because itamp;#39;s so two noble we can really tightly control the behavior of those cells whereas previous strategies for doing so have been insufficient so far our collaborators at UCSF have a have a sibling paper alongside this one where theyamp;#39;ve actually implemented feedback control upon naturally occurring proteins in the cell using diagram logger and so thatamp;#39;s thatamp;
