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Special stains are essential in pathology as they address specific inquiries that general stains do not. While hematoxylin and eosin (H&E) provides an overview of tissue and pathological processes, special stains offer detailed insights into cell types and tissue composition. They are vital for diagnosing cancer and various medical diseases, often used to identify conditions beyond cancer itself. For instance, special stains can detect mucin in adenocarcinoma cases, aiding in the determination of cancer presence. However, most applications of special stains go beyond cancer diagnosis.