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In this video, Dr. Nussey discusses three key medical conditions that can lead to disqualification during the Department of Transportation (DOT) physical exam, based on guidelines from the certified medical examiners handbook provided by the FMCSA. While these conditions are not exhaustive, they are significant for drivers to be aware of. Additionally, he mentions one condition that has recently been removed from the disqualification list, though it still requires meeting certain criteria. Dr. Nussey aims to inform viewers about these changes to help them prepare for their DOT physical exams and encourages subscriptions to his channel for more updates.