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This series explores the history of drugs, starting with the Sumerians in ancient Mesopotamia around 4,000 BC, the first known civilization. As they developed written language, they documented various fields including pharmacy. By 2,000 BC, their pharmacy compendia featured plant-based remedies such as ointments and infusions made from herbs like poppies, peppermint, mandragora, and thyme. The Sumerians recognized the medicinal properties of cannabis and morphine and utilized animal organs and excreta for their supposed healing qualities. This foundational knowledge paved the way for the evolution of medicine throughout history.