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Dr. Rishi Desai from Osmosis shares three essential tips for taking an effective patient history. While the mechanics involve gathering a chief complaint, history of present illness (HPI), past medical history, medications, allergies, family history, social history, and a review of systems, the focus is on the approach. His first tip emphasizes the importance of listening well and empathizing with patients, recognizing that they seek human interaction rather than mechanical questioning. This connection is crucial for gathering accurate and comprehensive information during the patient history-taking process.