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hi Im Alan hirahara to talk about bone void defects demonize bone matrix is an allograft bone within organic mineral removed it contains only the organic collagen matrix as first discovered by Marshall earnest in 1965 it exposes more biologically active bone morphogenetic proteins DBM is more biologically active than undie mineralized bone grafts this is very beneficial when trying to deal with this kind of a problem this is an example of a knee post ACL which failed and had actual bone tunnel widening the problem is what to do with this at this point we now have large bony defects which cannot just have a revision primary ACL done we need to go back and fill these bone defects with something in order to have bone reform the a ology of ACL tunnel widening has been variable is biological as well as mechanical aspects we know that this novel fluid propagation can inhibit the healing and reformation of bone we know also there may be increased cytokine levels that sterilization methods an
