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In this tutorial on nuclear medicine physics, the focus is on positron emission tomography (PET). A positron, a component of the electron, annihilates upon meeting an electron, resulting in the emission of two back-to-back photons. By using a ring of detectors, these photons can be detected, establishing the line of their origin. This process occurs when a radioactive substance emitting positrons is inside the body, leading to photon emission. This differs from single photon emission computed tomography (SPECT), which only detects one photon. The lecture also covers different radioisotopes that can be used in PET imaging.