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Historically, many medical treatments now seem barbaric and primitive due to a lack of understanding of the human body, with diseases often attributed to evil spirits or bad luck. One of the most dangerous practices was treponation, a surgical method where a hole is drilled or scraped into the skull to expose the brain, believed to treat various ailments. Evidence of treponation dates back to neolithic times, with indications of its practice in cave paintings and ancient burial sites. Individuals displaying abnormal behavior were sometimes subjected to this procedure to release supposed evil spirits or as a general treatment for conditions like seizures and epilepsy.