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For centuries, humans have been using substances to alter their state of mind. From caffeine, cigarettes and alcohol to more extreme drugs. But as the most commonly used illicit drug in North America, Where does marijuana fit in and how exactly does it affect your brain? First, we need to understand how the brain functions. Neurons are the cells that process information in the brain. By releasing chemicals called neurotransmitters from the axon of one neuron to the dendrite of another they change the electrical charge of the receiving neuron consequently exciting or inhibiting it. If excited, the signal is passed on. Though it sounds simple these signals work together and the effect is quickly compouned into complex configurations within milliseconds flashing over the entire brain. This is what happens every single time you think, breathe or move. So what is going on inside your brain when youre smoking marijuana? Well unlike alcohol, which contains molecules nothing like those in our