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the last study we did was a study of a little bit more than 150 patients where we looked at the rdq is a measure of change and we found that the rdq was sensitive to change and all the subscale on the rdq was sensitive to change in so far as patient scores at 3 months after initiating treatment was sign docHubly lower than their Baseline scores the effect size was large for the overall scale and it was equal in magnitude to the Hamilton depression rating scale and the quids we replicated our prior finding that the rdq was docHubly associated with self-reported remission status after controlling for the quids but the reverse was not true the quids was not associated with patients self-report of remission after controlling for the rdq so our conclusion from these series of studies is that patients Define remission much more broadly than has thus far been defined in the literature increasingly in recent years treatment studies of depression have not been limited to just evaluati