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The NMDA receptor is one of two main types of receptors activated by glutamate, the other being the AMPA receptor. These receptors often coexist at the same synapse, such as in the CA1 region of the hippocampus. Weak electrical stimulation of the presynaptic neuron releases glutamate, which binds to both receptors. Typically, weak stimulation activates only the AMPA receptors, leading to slight depolarization of the postsynaptic neuron. When glutamate binds to the NMDA receptor at slightly depolarized resting membrane voltages, few ions pass through because the channel's pore is blocked by magnesium ions, restricting ion flow.