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In this video tutorial, Veronica from Michigan Medical School's Office of Research explains the key aspects of cooperative agreement funding mechanisms, specifically NIH U-type grants. She highlights the significant role of funding agency staff in these agreements, contrasting them with typical grant mechanisms such as NIH R-type grants. Cooperative agreements aim to support investigator-driven research, requiring higher levels of scientific and administrative involvement from funding agency staff compared to standard grants. Veronica emphasizes the importance of understanding the unique nature of cooperative agreements before applying for this type of funding.