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In this video weamp;#39;ll learn about lead optimization, toxicity, and animal studies. Weamp;#39;ll focus on the different factors that are relevant for improving or optimizing the activity of a lead, and then weamp;#39;ll discuss how animal studies are so important for predicting the activity that a molecule may show in humans. Once a lead has been selected, the medicinal chemistry team will begin to modify the structure of that lead molecule in order to improve its properties. What properties will be optimized? Four properties for lead optimization are on the screen. One is potency. Hits and leads are fairly potent, meaning they affect the drug at a somewhat low concentration. During lead optimization, chemists will try to improve potency so that you can decrease the dose of the drug. Low-dose drugs tend to be safer. A second property of efficacy, which is related to the magnitude of a drugamp;#39;s effect, a magnitude of how the drug affects the target protein. A third property